Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y Two phenylquinolinones, including one new compound 1 and a previously isolated compound 2 , were isolated from the ethyl acetate extracts of the fungus Aspergillus versicolor Y, which was obtained from seawater samples collected from the Indian Ocean. The structures of these compounds were established by spectroscopic analyses. To the best of our knowledge, this study represents the first reported account of the isolation of compounds 1 and 2 as the secondary metabolites of the seawater derived fungus Aspergillus versicolor from the Indian Ocean. Activation of dormant secondary metabolite production by introducing neomycin resistance into the deep-sea fungus , Aspergillus versicolor ZBY A new ultrasound-mediated approach has been developed to introduce neomycin-resistance to activate silent pathways for secondary metabolite production in a bio-inactive, deep-sea fungus , Aspergillus versicolor ZBY Upon treatment of the ZBY-3 spores with a high concentration of neomycin by proper ultrasound irradiation, a total of 30 mutants were obtained by single colony isolation. The acquired resistance of the mutants to neomycin was confirmed by a resistance test. In contrast to the ZBY-3 strain, the EtOAc extracts of 22 of the 30 mutants inhibited the human cancer K cells, indicating that these mutants acquired a capability to produce antitumor metabolites. Compound 3 was a new compound; 2 was isolated from a natural source for the first time, and all of these compounds were also not yet found in the metabolites of other A.
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He wants me to sit around while he does his stuff. Well, maybe not a total disaster, that is a bit exaggerated. He did 5 years of residency and a one year fellowship and has been in practice for nearly 7 years. It's the extra socializing, hanging out with residents, stopping by the hospital to visit his best friend. And our strength doesn't necessarily come from ego or wealth.
You will have to convert and betray your ideals to keep the relationship alive. I wish I could reach out to this girl and tell her not to pass up an awesome guy. Do you and your girlfriend have any kind of plan for how you're going to manage your relationship while you're both in residency.